VAXCYTE, INC. (PCVX)

Healthcare · Biological Products, (No Diagnostic Substances) · Price $59.84
Updated: Aug 29, 2026
Below Average Equity Returns — Healthcare
ROE of -37.57% — below the 10% floor Zyberno applies to Healthcare businesses.
ROE
-37.57%
Return on Equity
ROIC
-32.49%
Return on Invested Capital
ROA
-33.62%
Return on Assets
Debt/Equity
0.04x
Leverage Ratio
Book Value/Share
$19.09
Equity Per Share

🧮 PCVX ROE Calculation

ROE = Net Income / Shareholders' Equity
Net Income (TTM) $-1.1B
Shareholders' Equity $2.8B
Total Debt $115.4M
Debt-to-Equity Ratio 0.04x
ROE (Return on Equity) -37.57%

Understanding ROE

Return on Equity (ROE) measures how efficiently a company generates profits from shareholders' equity. For PCVX, the current ROE is -37.57%.

Why ROE Matters

Warren Buffett has called ROE one of his favorite metrics because it shows how well management uses shareholders' capital to generate returns. A company that consistently earns 15%+ ROE is typically a well-run business that creates value for shareholders.

ROE Benchmarks

Excellent: >20%

Exceptional returns on equity. Often indicates strong competitive advantages. Common in capital-light businesses.

Good: 15-20%

Above-average ROE. Buffett often looks for companies in this range or higher.

Average: 10-15%

Typical for most companies. Returns are reasonable but not exceptional.

Below Average: <10%

May indicate poor capital allocation or challenging business conditions.

The DuPont Analysis

ROE can be decomposed into three components using DuPont analysis:

ROE = Net Margin × Asset Turnover × Equity Multiplier

This breakdown reveals whether high ROE comes from high profitability (good), efficient asset use (good), or high leverage (potentially risky).

ROE vs ROIC: Which is Better?

ROIC: -32.49% →

ROIC measures returns on ALL capital. It's more comprehensive and less affected by leverage. Often considered the better quality metric.

ROE: -37.57%

ROE only measures returns on equity. Can be inflated by high debt. If ROE >> ROIC, the company uses significant leverage.

Owner Earnings: $-779.6M →

Shows actual cash available to owners. Use alongside ROE and ROIC for complete analysis.

Net Income: $-1.1B →

The numerator in ROE. Understanding net income trends helps explain ROE changes over time.

What to Look For

📊 Full PCVX Stock Report

Intrinsic value, margin of safety, DCF valuation, and 250+ metrics.

🏆 PCVX ROIC

Compare ROE to ROIC — the more comprehensive measure of capital efficiency.

💹 PCVX P/E Ratio

Analyze valuation relative to earnings and understand market pricing.

👤 PCVX Owner Earnings

Warren Buffett's preferred measure of true economic earnings available to owners.

💰 PCVX Net Income

See the earnings that drive ROE calculations.

💵 PCVX Free Cash Flow

Actual cash generation after capital expenditures.

View Full PCVX Report Find More Quality Stocks
📊 Valuation Trilogy
Three interconnected metrics built on Owner Earnings
💎
Intrinsic Value
DCF Fair Value
🛡️
Margin of Safety
Valuation Gap
🎯
Expected Return
Projected Annual
Click any metric for full methodology and detailed analysis

Summary: PCVX Return on Equity

VAXCYTE, INC. (PCVX) has a ROE of -37.57% — below the 10% floor Zyberno applies to healthcare companies where IP and regulatory advantages drive equity returns, indicating weak returns on shareholders' capital. With a debt-to-equity ratio of just 0.04x, Zyberno notes these returns are being generated with minimal leverage — a particularly strong signal of underlying business quality. For complete financial analysis, view the full PCVX stock report on Zyberno.

Frequently Asked Questions

What is PCVX's current ROE?

VAXCYTE, INC.'s Return on Equity (ROE) is -37.57%, measured against the 20% excellent threshold Zyberno applies to Healthcare businesses. ROE measures the company's profitability relative to shareholders' equity.

Is PCVX's ROE good?

VAXCYTE, INC. (PCVX) has a ROE of -37.57% — below the 10% floor Zyberno applies to healthcare companies where IP and regulatory advantages drive equity returns, indicating weak returns on shareholders' capital.

What is the difference between ROE and ROIC?

ROE measures returns on shareholder equity only, while ROIC measures returns on all invested capital (debt + equity). PCVX's ROE is -37.57% vs ROIC of -32.49%. ROE can be inflated by high debt, making ROIC often a more reliable quality metric.

Can high ROE be misleading?

Yes, high ROE can be misleading if achieved through high debt. PCVX's debt-to-equity ratio is 0.04x. Compare ROE to ROIC — if ROE is much higher than ROIC, the company uses significant leverage which adds risk.

📊 Full PCVX Stock Report

See PCVX's intrinsic value, margin of safety, DCF valuation, and complete financial analysis with 250+ metrics.

🏆 PCVX ROIC

Compare to Return on Invested Capital — the most comprehensive measure of capital efficiency.

💹 PCVX P/E Ratio

Analyze the price-to-earnings ratio and earnings yield as a valuation metric.

🎯 PCVX Earnings Surprise (SUE)

See whether PCVX is beating or missing its own earnings trend — Standardized Unexpected Earnings and post-earnings drift.

👤 PCVX Owner Earnings

Warren Buffett's preferred measure of true economic earnings available to owners.

💰 PCVX Net Income

See the bottom-line profit that drives return calculations.

📊 PCVX EPS

Earnings per share — net income on a per-share basis.

View Full PCVX Report Find More Quality Stocks
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