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ZYBERNO

Stock Report

Updated Aug 30, 2026

CRISPR THERAPEUTICS AG (CRSP)

Healthcare • NASDAQ

$57.72

CRISPR Therapeutics AG is a Swiss-American gene editing company headquartered in Zug, Switzerland, with operations in Cambridge, Massachusetts, that develops therapies using CRISPR/Cas9 gene editing technology. The company co-developed Casgevy (exagamglogene autotemcel) with Vertex Pharmaceuticals, approved in late 2023 as the first CRISPR gene editing therapy for sickle cell disease and transfusion-dependent beta thalassemia.

Professional Investment Analysis

ZYBERNO SCORE →

Is it a great business? Is it getting better?

29.0/100

POOR BUSINESS

CRISPR THERAPEUTICS AG (CRSP) scores 29/100 — concerning metrics indicating significant structural or financial risks.

📊 How is the Zyberno Score calculated? +

The Zyberno Score answers one question: "Is this a quality business worth owning?" It's a 0-100 investment grade that evaluates business fundamentals across four critical dimensions, based on principles from Warren Buffett, Benjamin Graham, Peter Lynch, and Charlie Munger.

The 4 Core Categories (25 points each):

1. PROFITABILITY (25 pts)

Metrics: ROE, ROIC, Net Margin, Operating Margin
Thresholds: ROE >20% excellent • ROIC >20% excellent • Net Margin >20% excellent • Operating Margin >25% excellent

2. FINANCIAL STRENGTH (25 pts)

Metrics: Debt-to-Equity, Current Ratio, Interest Coverage, Altman Z-Score
Thresholds: D/E <0.3 excellent • Current Ratio >2.5 excellent • Interest Coverage >10x excellent • Altman Z >3.0 safe

3. CASH FLOW QUALITY (25 pts)

Metrics: Free Cash Flow, OCF vs Net Income, FCF Margin
Thresholds: Positive & growing FCF excellent • OCF/NI >1.2x excellent (cash earnings exceed accounting)

4. GROWTH & CONSISTENCY (25 pts)

Metrics: Revenue Growth, Net Income Growth, FCF Growth, Piotroski F-Score
Thresholds: Growth via log-linear regression • Piotroski 8-9 excellent, 6-7 good

Score Interpretation:

75-100

GREAT BUSINESS

65-74

GOOD BUSINESS

50-64

AVERAGE BUSINESS

30-49

WEAK BUSINESS

0-29

POOR BUSINESS

→ View full CRSP quality analysis & detailed breakdown

VALUATION SIGNAL

N/A (Requires more data)

Requires fair value calculation and current price data

💰 How is Margin of Safety calculated? +

Margin of Safety measures how much discount or premium you're paying relative to a stock's intrinsic value. It's Benjamin Graham's core principle: the larger the margin, the lower your downside risk.

Formula: (Intrinsic Value − Current Price) ÷ Intrinsic Value × 100%

How We Calculate Intrinsic Value (DCF Method):

Step 1: Calculate current Owner Earnings (OCF − Maintenance CapEx)

Step 2: Calculate company-specific growth rate using log-linear regression on 16 quarters of Owner Earnings

Step 3: Project 10 years forward using the calculated growth rate

Step 4: Discount each year's cash flow to present value using 10% discount rate

Step 5: Calculate terminal value using 3% perpetual growth rate

Step 6: Sum all discounted cash flows = Intrinsic Value

What The Percentages Mean:

+50% or more

EXCELLENT — Very undervalued

+25% to +50%

GOOD — Attractive discount

0% to +25%

FAIR — Reasonable value

0% to -25%

CAUTION — Slight premium

-25% or worse

POOR — Overvalued

"Price is what you pay, value is what you get." — Warren Buffett

→ View full CRSP valuation analysis · → View full CRSP Brina Gap analysis

📈 How is Brina Gap calculated? +

Brina Gap measures the difference between the growth a business can fundamentally sustain and the growth the market is already pricing in.

Formula: Fundamental Growth Rate − Market-Implied Growth Rate

The Two Components:

Fundamental Growth Rate = ROIC × Reinvestment Rate

What the business can sustainably grow at based on how much it reinvests and what return it earns on that capital. Grounded in historical financials.

Market-Implied Growth Rate = Reverse DCF

The growth rate the current Enterprise Value implicitly assumes. Calculated by back-solving a 10-year DCF model (10% WACC, 3% terminal growth) until the present value of projected cash flows equals EV.

What The Gap Means:

Gap > +5% Market Underestimates — potential upside

+2% to +5% Slight Underestimate

-2% to +2% Fairly Priced — market consensus matches fundamentals

-5% to -2% Slight Overestimate

Gap < -5% Market Overestimates — price embeds optimism fundamentals don't support

A positive gap (market underestimates) combined with a positive Margin of Safety is the strongest combined signal — the business is both cheap historically and forward economics are stronger than the price suggests.

Critical Financial Health Indicators

Return on Equity (Profitability):CRITICAL (-24.4%)

Debt-to-Equity (Solvency Risk):GOOD (0.45x)

Operating Margin (Operational Efficiency):CRITICAL (-13,023.2%)

Return on Capital (Capital Efficiency):CRITICAL (-19.5%)

📊 Valuation Trilogy

Three interconnected metrics for complete valuation analysis

Click any metric for full methodology and detailed analysis

Zyberno's Verdict

CRISPR THERAPEUTICS AG (CRSP) stock report — Zyberno Score 29/100 (POOR BUSINESS). Full financial analysis on Zyberno.

Over the trailing twelve months, CRSP generated -$401.18M in Owner Earnings. Capital was deployed as follows: $1.21M invested in capital expenditures. Reinvestment rate: 4.6%.

DIVISION I: EXECUTIVE SUMMARY

A. Market Valuation

Market Price & Capitalization (2)

Current Price:57.72

Market Cap:$5.57B

Valuation Multiples (3)

P/B Ratio:3.19x

P/S Ratio:1,357.74x

Peg Ratio:-999.00x

Enterprise Metrics (1)

Enterprise Value:$5.88B

Price Action & Momentum (3)

12-1 Momentum:

-17.3% (56th pctile)

📈 Click to view full CRSP Momentum analysis →

Momentum Percentile:56 / 100

% of 52-Week High:73.5%

B. Profitability Assessment

Return Metrics (5)

ROE:

-24.4%

📊 Click to view full CRSP ROE analysis →

ROA:-18.3%

Roic:

-19.5%

📊 Click to view full CRSP ROIC analysis →

Reinvestment Rate:4.6%

Fundamental Growth Rate (g):-0.9%

Margin Analysis (3)

Operating Margin Ttm:-13,023.2%

Net Margin Ttm:-10,995.3%

Ebitda Margin:-12,567.1%

TTM Performance (2)

Operating Margin Ttm:-13,023.2%

Net Margin Ttm:-10,995.3%

Yield Metrics (2)

Earnings Yield:-$8.16

Dividend Yield:0.0%

C. Log-Linear Regression Growth Trends

Earnings Surprise (SUE) (3)

Earnings Surprise (SUE):

+0.75

📊 Click to view full CRSP Earnings Surprise analysis →

EPS Surprise vs Expected:73.3%

Latest Earnings Filed:2026-08-03

Revenue Growth (Linear) (1)

Revenue Growth Rate (Linear):51.8%

D. Financial Stability

Liquidity Ratios (3)

Current Ratio:17.85x

Quick Ratio:17.85x

Cash Ratio:2.19x

Leverage Analysis (3)

Debt To Equity Ttm:0.45x

Debt-to-Equity Ratio:0.45x

Debt To Ebitda:-999.00x

Coverage Ratios (2)

Interest Coverage Ratio:-199.93x

Times Interest Earned:-199.93

Capital Structure (4)

Working Capital:2,238,874,000.00

Cash And Cash Equivalents:291,337,000.00

Long Term Debt:$586.20M

Net Debt:$313.51M

DIVISION II: FINANCIAL STATEMENTS ANALYSIS

A. Income Statement Analysis

Revenue Components (2)

Revenue TTM: $4.10M

Linear Growth: 51.8%

📊 Click to view full CRSP Revenue analysis & methodology →

Cost Of Revenue Ttm:$0.00

Profitability Breakdown (2)

$0.00-$534.34M

Bottom Line Performance (3)

-$451.14M

Income Before Tax:-$448.11M

Ebitda Ttm:-515,627,000.00

Operating Expenses (5)

Operating Expenses:547,732,000.00

R And D Expense:278,154,000.00

Sga Expense:70,066,000.00

Income Tax Expense:$3.03M

Interest Expense:3,324,000.00

Expense Ratios (3)

R And D To Revenue Percentage:19,077.8%

Sga To Revenue Percentage:4,805.6%

Ebitda Margin:-12,567.1%

B. Balance Sheet Analysis

Asset Composition (5)

Total Assets:$2.65B

Current Assets:$2.37B

Ppe Net:108,068,000.00

Goodwill:0.00

Intangible Assets:$0.00

Liability Structure (4)

Total Liabilities:904,219,000.00

Current Liabilities:132,896,000.00

Long Term Debt:$586.20M

Short Term Debt:$18.65M

Equity & Capital (3)

Equity:$1.75B

Retained Earnings:-$2.16B

Common Stock:144,447,967.00

Working Capital Items (3)

Accounts Receivable:0.00

Inventory:0.00

Accounts Payable:70,278,000.00

Special Items (2)

Contract Liabilities:15,189,000.00

Stock Based Compensation:17,316,000.00

C. Cash Flow Analysis

Operating Activities (2)

-$399.96M-$401.18M

Investment Activities (2)

Investing Cash Flow:-$410.74M

Capital Expenditures Ttm:1,212,000.00

Financing Activities (3)

Financing Cash Flow:$591.91M

Dividends Paid Ttm:0.00

Stock Repurchase:0.00

Capital Transactions (3)

Common Stock Issuance:-722,000.00

Long Term Debt Issuance:$0.00

Long Term Debt Repayments:$0.00

Non-Cash Items (1)

Depreciation Amortization Ttm:18,713,000.00

DIVISION III: OPERATIONAL METRICS

A. Per Share Analysis

Earnings Per Share (3)

EPS (Basic TTM):-4.71

-$4.71

Earnings Per Share Ttm:-$4.67

Revenue & Cash Per Share (2)

Sales Per Share Ttm:0.04

Operating Cash Flow Per Share:-$3.57

Book Value & Capital (2)

Book Value Per Share:$18.10

Cash Per Share:3.02

Dividend Policy (1)

Dividend Payout Ratio:-999.00x

B. Operational Efficiency

Asset Utilization (2)

Asset Turnover Ttm:0.00x

Working Capital Turnover Ttm:0.00x

Receivables Management (2)

Receivables Turnover Ttm:-999.00x

Days Sales Outstanding Ttm:-999.00

Inventory Management (2)

Inventory Turnover Ttm:-999.00x

Days Inventory Outstanding Ttm:-999.00

Payables & Cash Cycle (2)

Days Payable Outstanding:6,251.88

Cash Conversion Cycle:-8,249.88

C. Quality & Risk Metrics

Financial Quality Scores (2)

Financial Strength Score:80.00

Quality Score:35.00

Market Metrics (2)

Beta:0.00x

Volatility Category:unknown

DIVISION IV: INVESTMENT ANALYSIS

A. Value Investment Framework

Owner Earnings Analysis (1)

-$401.18M

Damodaran Growth Analysis (2)

Reinvestment Rate:4.6%

Fundamental Growth Rate (g):-0.9%

B. Log-Linear Regression Growth Analysis

Growth Rates (Log-Linear Regression) (1)

Revenue Growth Rate (Linear):51.8%

Other Growth Rates (1)

Book Value Growth Rate (Linear):-2.9%

C. Company Profile & Context

Corporate Information (6)

Symbol:CRSP

Company Name:CRISPR THERAPEUTICS AG

Sector:Healthcare

Industry:Biological Products, (No Diagnostic Substances)

Exchange:NASDAQ

Country:United States

Market Classification (3)

Market Cap Category:N/A

Price Category:high

Volume Category:N/A

Share Structure (3)

Shares Outstanding:96.51M

Shares Outstanding Basic:96.51M

Shares Outstanding Diluted:96.51M

Data Processing Info (3)

Processing Version:v3.0

Last Updated:2026-08-30 05:48:40 UTC

Data Timestamp:2026-08-30T05:48:40.583494